Status:
NOT_YET_RECRUITING
Comparison of Bone Microarchitecture Analysed by HRpQCT and pQCT in Pathologies With Bone Loss and/or Muscle Loss
Lead Sponsor:
Centre Hospitalier Universitaire de Saint Etienne
Conditions:
Osteoporosis Risk
Bone Loss
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The study aims to utilize medical devices, such as the Xtreme CT and XCT 3000, to assess bone and muscle microarchitecture for various pathologies. The devices provide crucial data on bone and muscle ...
Eligibility Criteria
Inclusion
- For the patients:
- Women or men treated at the Saint-Etienne University Hospital and presenting an osteoporotic risk with one of the following associated pathologies:
- Osteoporosis defined by: History of a documented brittle bone fracture
- Bone fragility: Patient with indication for bone densitometry but no history of fracture
- Inflammatory joint disease:
- Rheumatoid arthritis
- Spondyloarthritis
- Chronic kidney disease
- Endocrinopathies:
- Primary hyperparathyroidism
- Constitutional thinness
- Anorexia nervosa
- Obesity (BMI \>30)
- Sarcopenia
- Neuropathies - Parkinson's disease
- For the controls:
- Acute episode of spinal or radiculalgia (less than one month old) with corticosteroid treatment of less than 1 month Signature of written consent
Exclusion
- No sign written consent
- For the controls:
- Medications inducing bone loss:
- anti-aromasin or GnRH agonist for at least 6 months,
- corticosteroids (dose ≥ 5 mg/d for 6 months)
- anti-epileptic drugs: carbamazepine, phenobarbital, phenytoin, primidone, valproic acid for at least 6 months)
- History of fracture due to bone fragility
- Taking bone-targeting medication (biphosphonate, teriparatide, strontium ranelate)
Key Trial Info
Start Date :
July 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2035
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT06541548
Start Date
July 1 2025
End Date
May 1 2035
Last Update
July 8 2025
Active Locations (1)
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1
Chu Saint Etienne
Saint-Etienne, France, 42055