Status:
COMPLETED
Implication of Long Non-coding RNA HOTTIP Haplotype on Liver Cancer Metastasis
Lead Sponsor:
Ain Shams University
Conditions:
Hepatocellular Carcinoma
Eligibility:
All Genders
35+ years
Brief Summary
Hepatocellular carcinoma (HCC) represents the fourth common cancer and the most common cause of mortality-caused and morbidity-related cancer. Different reports implied several lncRNAs role in the pro...
Detailed Description
1. Introduction Hepatocellular carcinoma HCC is a complex disease, which could be caused by viruses as hepatitis B and C infection, drug abuse, and chemicals such as aflatoxin. However, treatments for...
Eligibility Criteria
Inclusion
- HCC patients attending the Faculty of Medicine, Ain Shams University Hospital, with 1:1 or 1:2 ratio for the HCC groups metastatic vs non metastatic HCC groups (according to clinical evidence/relevance and/or availability).
- Group 1; non-metastatic HCC patients, Group 2; metastatic HCC patients, diagnosed with primary HCC receiving any type of therapy (neoadjuvant or radiotherapy).
- Eligibility criterion are adult age and male/female 1:1 according to availability.
- Criteria for HCC diagnosis following the ASU hospital role relying on AFP level and CT scan or the fine needle biopsy.
- Groups to be matched socioeconomically, in age range, residence (case-controlled study).
Exclusion
- HCC patients who have history of liver transplantation, have other cancer types at the time of selection, presented by renal insufficiency, and thyroid dysfunction will be excluded from the study. Additionally, patients with incomplete data or histopathology diagnosis.
Key Trial Info
Start Date :
March 16 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
198 Patients enrolled
Trial Details
Trial ID
NCT06544005
Start Date
March 16 2022
End Date
December 31 2024
Last Update
April 24 2025
Active Locations (1)
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1
Faculty of Pharmacy, Ain Shams Univeristy, Advanced Biochemistry Research Lab.
Cairo, Egypt