Status:
RECRUITING
Effectiveness and Biological Mechanism of Direct Ischemic Post-conditioning for Acute Stroke Patients Due to Large Vessel Occlusion
Lead Sponsor:
Tianjin Huanhu Hospital
Conditions:
Stroke, Acute
Neuroprotection
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The goal of this clinical trial is to determine if direct ischemic post-conditioning (IPostC) can alleviate ischemic-reperfusion injury (I/R) in patients who have undergone endovascular thrombectomy (...
Eligibility Criteria
Inclusion
- Ischemic stroke confirmed by CT or MRI.
- Large vessel occlusion confirmed by CTA or MRA, including the intracranial internal 3. carotid artery (ICA) and middle cerebral artery (MCA M1/M2).
- 4\. Recanalization of the occluded vessel at eTICI grade 2b/3, confirmed by DSA after thrombectomy.
- 5\. The patient or legally authorized representative has signed an informed consent form.
Exclusion
- Inability to perform an MRI or CT scan for any reason.
- Presence of any condition that would interfere with neurological assessment or any psychiatric disorders.
- Stroke onset accompanied by seizures, resulting in the inability to obtain an accurate NIHSS baseline.
- Pregnancy.
- Presence of other serious, advanced, or terminal illnesses.
Key Trial Info
Start Date :
February 5 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06545734
Start Date
February 5 2023
End Date
September 1 2024
Last Update
August 9 2024
Active Locations (1)
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1
Tianjin Huanhu Hospital
Tianjin, Tianjin Municipality, China, 300070