Status:
RECRUITING
The Effect of Melatonin Supplementation on Cumulus Cells and IVF Outcomes
Lead Sponsor:
Kaohsiung Veterans General Hospital.
Conditions:
Unrecognized Condition
Eligibility:
FEMALE
35-45 years
Phase:
NA
Brief Summary
This study investigates the effects of melatonin supplementation on cumulus cell gene expression and in vitro fertilization (IVF) outcomes in women over 35 years old. In the study group, patients will...
Detailed Description
Aging in female reproductive cells, particularly cumulus granulosa cells, is associated with various dysfunctions that compromise fertility. Melatonin, a hormone primarily produced by the pineal gland...
Eligibility Criteria
Inclusion
- Age 35-45 years
- BMI 18-30 kg/m2
- planning to undergo IVF cycles
Exclusion
- Primary ovarian insufficiency
- history of oophorectomy
- receiving oocyte donation
- Chromosome anomaly
- Congenital uterine anomaly
- Severe intrauterine adhesion
- Malignancy
- Using hormone therapy or supplements in recent 3 months
Key Trial Info
Start Date :
May 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06546774
Start Date
May 1 2021
End Date
December 31 2025
Last Update
August 13 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Kaohsiung City, Taiwan, 886