Status:
COMPLETED
The Fondazione Genomic SARS-CoV-2 Study COVID-19
Lead Sponsor:
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Conditions:
COVID-19
Genetic Predisposition
Eligibility:
All Genders
Phase:
NA
Brief Summary
Genetic association at the genomic level (genomewide association study - GWAS), requencing by NGS (whole exome sequencing) and gene expression studies to identify the main ones hereditary genetic dete...
Detailed Description
Lombardy region in Northern Italy is now in the midst of an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19) . The CO...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Cohort 1 inclusion criteria:
- SARS-CoV-2 positive patients (no age limit) with severe pulmonary compromise, hospitalized with failure respiratory that requires support of any kind
- Signature of informed consent
- Cohort 2 inclusion criteria:
- Blood donors (18-70 years old) who donated between 24/02/2020 and 31/12/2021
- exposure to the SARS-CoV-2 virus confirmed by viremia positive and presence of IgG/IgM
- Signature of informed consent
- Cohort 3 inclusion criteria:
- Healthy controls available from previous studies (n=5,000, ages 14-80 years), whose data are already available for genetic association analyses within the Kiel University database.
Exclusion
Key Trial Info
Start Date :
March 23 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2023
Estimated Enrollment :
4000 Patients enrolled
Trial Details
Trial ID
NCT06549712
Start Date
March 23 2020
End Date
May 31 2023
Last Update
May 2 2025
Active Locations (1)
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1
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Istituto di Ricovero e Cura a Carattere Scientifico di natura pubblica
Milan, Milano, Italy, 20122