Status:
RECRUITING
Clinical and Molecular Features of Oral Premalignancy and Oral Cancer
Lead Sponsor:
M.D. Anderson Cancer Center
Conditions:
Oral Cancer
Eligibility:
All Genders
18+ years
Brief Summary
Investigators will employ serial assessments of tissue biopsy and additional biomarkers that reflect burden of disease and predict treatment response. Patients enrolled on this study will be given the...
Detailed Description
Primary objectives: Current primary objectives need revision as they focus on diabetes which is not the focus of this study. * Investigators will examine the role of clinical, environmental, and gene...
Eligibility Criteria
Inclusion
- Aged 18 or older, with a diagnosis of oral premalignant or malignant tumors (eligible diagnoses listed below) or presenting with suspected premalignant or malignant tumors for definitive diagnosis
- Must be able to provide informed consent
- Oral premalignant or malignant tumors presenting for evaluation for the first time at UT MD Anderson Cancer Center
- Oral premalignant or malignant tumors who were previously treated or evaluated at UT MD Anderson Cancer Center who presents for evaluation of progressive or recurrent disease. Newly collected biospecimens and tissue samples will be linked to applicable samples previously collected and banked/stored under PA17-0050, LAB02-427, Lab02-039 and Lab08-0848.
- Eligible diagnoses include:
- Leukoplakia
- Erythroplakia
- Mild dysplasia
- Moderate dysplasia
- Severe dysplasia
- Carcinoma in situ
- Squamous cell carcinoma
- Exclusion:
- \- Pregnant women and/or cognitively-impaired adults are excluded from this study.
- Exclusion Criteria:
- \- Prior oral squamous cell carcinoma (OSCC) surgery or OSCC radiation treatment at a non-MDA institution.
Exclusion
Key Trial Info
Start Date :
October 31 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2066
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT06550050
Start Date
October 31 2024
End Date
December 31 2066
Last Update
October 24 2025
Active Locations (1)
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1
MD Anderson Cancer Center
Houston, Texas, United States, 77030