Status:

RECRUITING

Cardiopulmonary Adaptations to High-intensity Interval Training (HIIT) in COPD

Lead Sponsor:

Rigshospitalet, Denmark

Conditions:

COPD

Rehabilitation

Eligibility:

All Genders

40-80 years

Phase:

NA

Brief Summary

The aim of this prospective randomised controlled trial in which the impact of high intensity interval training (HIIT) on pulmonay blood volume, pulmonary gas exchange during exercise, and lung tissue...

Eligibility Criteria

Inclusion

  • Inclusion criteria
  • Men and women
  • Age \>=40 and \<80 years
  • COPD (GOLD stage I to III)
  • Modified Medical Research Council score (mMRC) of 0 to 3
  • Resting arterial oxygenation \> 90% Exclusion criteria
  • Symptoms of ischaemic heart disease
  • Known heart failure
  • Unable to complete or understand HIIT training
  • Claudication
  • Symptoms of disease within 2 weeks prior to the study
  • Participation in pulmonary rehabilitation within 3 months
  • Known malignant disease
  • Pregnancy
  • Unstable cardiac arrhythmic disease
  • Renal or liver dysfunction
  • Known chronic kidney or liver disease
  • Elevated creatinine, urea, alanine transaminase (ALAT), aspartate transaminase (ASAT), bilirubin, basic phosphatases at blood test
  • Completion of pulmonary rehabilitation within the last 3 months

Exclusion

    Key Trial Info

    Start Date :

    August 1 2024

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ESTIMATED

    End Date :

    August 1 2026

    Estimated Enrollment :

    66 Patients enrolled

    Trial Details

    Trial ID

    NCT06551441

    Start Date

    August 1 2024

    End Date

    August 1 2026

    Last Update

    August 13 2024

    Active Locations (1)

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    1

    Center For Physical Activity Research, Rigshospitalet

    Copenhagen, Denmark