Status:
RECRUITING
Thrombosis and Inflammation in Vessels Initiative (TIVI)
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Cardiovascular Diseases
Vascular Diseases
Eligibility:
All Genders
5-100 years
Brief Summary
Background: Diseases related to the immune system, blood clots, and blood vessels can affect every part of the body. These diseases are now known to be interrelated: People who have strokes, blood cl...
Detailed Description
Study Description: Thrombotic vascular disorders remain the leading cause of morbidity and mortality in the United States. The proximate determinants of thrombosis, arterial, venous, and lymphatic va...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- In order to be eligible to participate in this study, an individual must meet all of the following criteria:
- Age \>= 5 years at the time of consent
- Ability of subject or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent document
- In addition, the following cohort-specific inclusion criteria apply:
- Affected Subjects:
- Known or possible thrombotic, immune, or vascular disorder after review of the subject s medical records and/or discussion of medical history
- Relatives of Affected Subjects:
- Being a relative of an affected subject
- Unrelated Healthy Controls:
- In good general health as evidenced by medical history
- EXCLUSION CRITERIA:
- An individual who meets any of the following criteria will be excluded from participation in this study:
- Any condition that in the opinion of the Investigator would warrant exclusion
- Unrelated Healthy Controls:
- Unrelated healthy volunteers who decline to have blood drawn and/or tissue studies or who do not consent to have samples stored for future research
- Cognitively impaired individuals
Exclusion
Key Trial Info
Start Date :
November 22 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 30 2034
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT06552767
Start Date
November 22 2024
End Date
January 30 2034
Last Update
January 8 2026
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892