Status:
COMPLETED
Protein Digestion and Amino Acid Absorption in the Aging Gastrointestinal Tract
Lead Sponsor:
Maastricht University Medical Center
Collaborating Sponsors:
FrieslandCampina
Conditions:
Protein Malabsorption
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Rationale: Worldwide, the aging population is increasing. Aging is associated with loss of independence and increased risk of co-morbidity. Sufficient protein intake is imperative to maintain skeletal...
Detailed Description
Worldwide, the proportion of older individuals in the population is increasing. The progressive loss of skeletal muscle mass with aging, or sarcopenia, has a major impact on our health care system and...
Eligibility Criteria
Inclusion
- Aged 18-35 years or 67+ years
- Body mass index (BMI) between 18.5 and 30 kg/m2
- Regular stool frequency ranging from 1-3 times/day
Exclusion
- History of cardiovascular, respiratory, gastrointestinal, urogenital, neurological, psychiatric, dermatologic, musculoskeletal, metabolic, endocrine, haematological, immunologic disorders, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol, interfere with the execution of the experiment, or potential influence the study outcomes (to be decided by the principal investigator and responsible physician)
- Major abdominal surgery interfering with gastrointestinal function (upon judgement of the principal investigator and responsible physician)
- Use of medication which limit participation in or completion of the study protocol, interferes with the execution of the experiment, or potential influences the study outcomes (to be decided by the principal investigator and responsible physician)
- Use of supplementation (i.e. protein, vitamin, pre- and probiotic supplementation) within 14 days prior to testing
- Administration of investigational drugs or participation in any scientific intervention study prior or during the study, which may interfere with this study (upon judgement of the principal investigator and responsible physician) Specific diet (e.g. vegetarian, vegan, gluten free, no diary) within the study period
- Planning to lose weight during the study period
- Excessive alcohol consumption (defined as \> 14 alcoholic consumptions per week)
- Smoking
- Drug use
- Pregnancy
- Lactation
- Donated blood three months prior to the test day
- No given permission to register participation in electronic patient file at MUMC+ and to add records of gastroduodenoscopy
Key Trial Info
Start Date :
August 20 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 13 2025
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT06553794
Start Date
August 20 2024
End Date
June 13 2025
Last Update
September 15 2025
Active Locations (1)
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1
Maastricht University
Maastricht, Maastricht, Netherlands