Status:
COMPLETED
Acute and Long-term Health Effects of Various Carbohydrates on Blood Glucose Management in Humans
Lead Sponsor:
Singapore Institute of Food and Biotechnology Innovation
Conditions:
Nutrition, Healthy
Eligibility:
All Genders
21-60 years
Phase:
NA
Brief Summary
Dietary fibre, especially soluble fibre, has several health benefits such as lowering the risks for cardiovascular disease, stroke, diabetes, obesity, and gastrointestinal diseases. Resistant dextrin ...
Detailed Description
Dietary fibre has several health benefits such as lowering the risks for cardiovascular disease, stroke, diabetes, obesity, and gastrointestinal diseases. Dietary fibre intake has regularly been repor...
Eligibility Criteria
Inclusion
- 21 to 60 years old
- Group A: 21 - 25 kg/m2, with first degree family history of type 2 diabetes, or Group B: 23 - 30 kg/m2, with waist circumference \>85 cm for males and \>82 cm for females
Exclusion
- • Consume fibre supplements or any other supplements that is likely to interfere with study outcomes
- Have any major organ dysfunction (e.g. cardiovascular, respiratory, hepatic, renal, gastrointestinal) that may influence taste, olfaction, appetite, digestion, metabolism, absorption or elimination of test foods, nutraceutical or drug
- Smoking
- Have any metabolic diseases (e.g. diabetes, hypertension)
- Have medical conditions and/or taking medications known to affect glycaemia (e.g. glucocorticoids, thyroid hormones, thiazide diuretics)
- Have glucose-6-phosphate dehydrogenase (G6PD) deficiency
- Have any severe food allergy (e.g. anaphylaxis to peanuts), or any other known food allergy/intolerance
- Have active Tuberculosis (TB) or currently receiving treatment for TB
- Have any known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
- A team member of the study or their immediate family members (i.e. spouse, parent, child, or sibling, whether biological or legally adopted)
- Enrolled in a concurrent research study judged not to be scientifically or medically compatible with the study of the CNRC.
- Intentionally restricting food intake
- Have poor veins impeding venous access
- Have any history of severe vasovagal syncope (blackouts or near faints) following blood draws
- Have claustrophobia
Key Trial Info
Start Date :
August 14 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 14 2023
Estimated Enrollment :
98 Patients enrolled
Trial Details
Trial ID
NCT06554002
Start Date
August 14 2019
End Date
August 14 2023
Last Update
August 14 2024
Active Locations (1)
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1
Clinical Nutrition Research Centre (CNRC)
Singapore, Singapore, 117599