Status:
RECRUITING
Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension
Lead Sponsor:
University of Massachusetts, Boston
Collaborating Sponsors:
University of Illinois at Chicago
University of Alabama at Birmingham
Conditions:
Multiple Sclerosis
Hypertension
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this study is to determine if 12 weeks of cycling exercise training at home will improve three parameters: 1) blood pressure, 2) cognition, and 3) walking ability among persons with multip...
Detailed Description
Functionally, the disease pathophysiology of multiple sclerosis (MS) brings about a number of consequences, including cognitive dysfunction and mobility disability, which are two of the most prevalent...
Eligibility Criteria
Inclusion
- Persons with confirmed multiple sclerosis diagnosis with Expanded Disability Status Scale scores of 4-6.5, characteristic of 2nd stage of multiple sclerosis;
- Hypertension defined as elevated, or Stage 1 or 2, as per the 2017 American Heart Association guidelines (brachial systolic blood pressure \> 120 mmHg or brachial diastolic blood pressure \> 80 mmHg)
- Persons who are physically inactive (less than 60 min/wk of physical activity);
- Persons with body mass index \< 40 kg/m2;
- Persons who are not confined to a wheel chair;
- Multiple sclerosis relapse in the past 30 days;
- People with stable pharmacotherapy.
Exclusion
- People with additional cardiovascular comorbidities;
- People with type 1 diabetes mellitus;
- Physician disapproval to participating in the study;
- Space constraints to fit a cycle ergometer at the home of prospective participants.
Key Trial Info
Start Date :
April 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2027
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06554340
Start Date
April 15 2025
End Date
August 1 2027
Last Update
August 22 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
UMass Boston
Boston, Massachusetts, United States, 02125