Status:
COMPLETED
Annexin Levels of Periodontal Inflammatory Regulation
Lead Sponsor:
Medipol University
Conditions:
Periodontal Diseases
Inflammation
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
ANXA1, a member of the annexin family, plays a role in the resolution of inflammation and the regulation of anti-inflammatory responses, while ANXA2 is involved in the initiation of the inflammatory r...
Detailed Description
Healthy participants (n:25) and stage III, grade B periodontitis (n:25) patients enrolled for this study. Clinical periodontal parameters and PISA levels were noted. Serum, saliva, and GCF samples wer...
Eligibility Criteria
Inclusion
- systemically healthy
- clinical diagnosis of periodontitis
- clinical diagnosis of periodontal health
Exclusion
- • history of regular use of systemic antibiotics anti-inflammatory, or antioxidant drugs (previous 3 months)
- nonsurgical periodontal treatment (previous 6 months)
- surgical periodontal treatment (previous 12 months)
- presence of\<10 teeth
- current medications affecting gingival health (calcium channel blockers, phenytoin, cyclosporine, and hormone replacement therapy)
- diabetes
- diagnosis of rheumatoid arthritis
- pregnancy
- lactating
- smoking
- excessive alcohol consumption.
Key Trial Info
Start Date :
May 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 12 2024
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06554756
Start Date
May 15 2023
End Date
March 12 2024
Last Update
August 15 2024
Active Locations (1)
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1
Istanbul Medipol University, School of Dentistry
Istanbul, Fatih, Turkey (Türkiye)