Status:

RECRUITING

Cardio and Renovascular Effects of Isometric Exercise in the Healthy Human Measured by PET/CT and MRI

Lead Sponsor:

Bispebjerg Hospital

Conditions:

Kidneys

Eligibility:

MALE

18-60 years

Phase:

NA

Brief Summary

This randomized crossover study aims to validate measurements of renal perfusion in healthy males with PET/CT, using 15-oxygen labeled water as tracer, against the validated multiparametric MRI techni...

Detailed Description

Measuring tissue perfusion with PET/CT using 15-oxygen labeled water is routinely used as a non-invasive tool to examine cerebral and myocardial perfusion. With a 100% tissue extraction, 15-oxygen lab...

Eligibility Criteria

Inclusion

  • Normal health stated through medical questionnaire, examination and blood samples.

Exclusion

  • Immunosuppressive treatment
  • Alcohol abuse
  • Treatment with glucocorticoids, Glucagon-like peptide-1 (GLP-1) agonists, dipeptidyl peptidase 4 (DPP-4)-inhibitors
  • Medical treatment affecting insulin secretion or cardiovascular endpoints
  • Liver disease
  • Decreased kidney function
  • Severe claustrophobia
  • Elements incompatible with MR.

Key Trial Info

Start Date :

May 7 2024

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

December 1 2024

Estimated Enrollment :

10 Patients enrolled

Trial Details

Trial ID

NCT06555211

Start Date

May 7 2024

End Date

December 1 2024

Last Update

August 15 2024

Active Locations (1)

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1

Bispebjerg Hospital, Department of Clinical Physiology & Nuclear Medicine

Copenhagen, Capital Region, Denmark, 2400