Status:
COMPLETED
Activating the Cholinergic Anti-Inflammatory Pathway in Healthy Volunteers and People With Inflammatory Arthritis
Lead Sponsor:
Surf Therapeutics
Conditions:
Psoriatic Arthritis
Rheumatoid Arthritis
Eligibility:
All Genders
22-75 years
Phase:
NA
Brief Summary
This study is designed to investigate whether non-invasive ultrasound (US) that is optimized for stimulation and can elicit an anti-inflammatory response in people with Inflammatory Arthritis as compa...
Detailed Description
The CAP has demonstrated potential as a treatment for various autoimmune and inflammatory disorders, including inflammatory arthritis (Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis...
Eligibility Criteria
Inclusion
- Healthy Volunteer Population
- 22-75 years of age
- Weigh at least 40 kg
Exclusion
- Any physical disabilities, conditions, or diseases that limit the capacity to participate in study procedures or increase the risk of harm as determined by the study PI
- Unable to provide informed consent
- Active bacterial or viral infection
- Class II obesity with a BMI of 35 or higher
- Pregnant women or those trying to become pregnant
- Active use of tobacco/nicotine products
- History of substance use disorder or active regular use of substances (nicotine, marijuana, cocaine, psychedelics, stimulants, etc.)
- Splenomegaly, asplenia, or splenectomy
- Inflammatory Arthritis Population
- Inclusion Criteria:
- 22-75 years of age
- Weigh at least 40 kg
- Diagnosis of Rheumatoid Arthritis, Psoriatic Arthritis, or Axial Spondyloarthritis of at least 6 months duration as defined by ACR guidelines
- Able to continue the same stable dose of immunomodulatory medication(s) while participating in the study
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 5 2026
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT06555562
Start Date
October 1 2025
End Date
January 5 2026
Last Update
January 7 2026
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Tekton Research
Austin, Texas, United States, 78745
2
UT Health
Houston, Texas, United States, 77030