Status:
RECRUITING
Investigating the Effects of Transcranial Direct Current Stimulation to Different Brain Regions on Ankle Tracking Motor Learning, Motor Adaptation, and Brain Connectivity in Healthy Middle-aged and Older Adults and Patients With Subcortical Stroke
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Transcranial Direct Current Stimulation
Ankle
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
Ankle control is essential to safe over-ground navigation for humans. Middle- aged and older adults and patients with stroke whose ankle control is poor often lose their balance or fall. Transcranial ...
Eligibility Criteria
Inclusion
- Part 1: healthy middle-aged and older adults
- age between 40 and 80 years old
- intact cognitive function (MMSE ≧ 27)
- normal ankle dorsiflexor and plantarflexor strength (manual muscle strength testing= 5) and passive range of motion (ankle dorsiflexion ≧10 degrees; ankle plantarflexion ≧ 45 degrees)
- corrected far vision ≥ 0.8 (Landolt C test) and uncorrected near vision ≥ 0.04 (Comprehensive Color Blindness Checklist)
Exclusion
- Part 1: healthy middle-aged and older adults
- having any contraindications for MRI or tDCS;
- serious or uncontrolled systematic diseases;
- symptoms or history of neurological diseases, including transient ischemic attack, stroke, epilepsy, history of abnormal electroencephalogram (EEG), meningitis, encephalitis, brain tumors, brain surgery, and sensory disorders, etc.;
- severe musculoskeletal problems that would affect lower limb functions;
- visual spatial perception disorders and hearing loss;
- color blindness;
- depression and psychiatric disorders;
- use of any medication that could affect the central nervous system function;
- drug, substance, or alcohol addiction;
- those participating in research involving invasive or non-invasive brain stimulation;
- those deemed unsuitable for MRI or tDCS after evaluation by the attending physician;
- those affiliated with any research-conducting institution.
- Inclusion Criteria: Part 2: patients with chronic subcortical stroke
- aged between 40 and 80 years old;
- intact cognitive function (MMSE ≥ 27);
- first-ever onset of subcortical stroke occurring at least 3 months prior to enrollment, with brain lesions involving unilateral subcortical regions only;
- hemiplegic or hemiparetic;
- no spatial neglect;
- able to actively perform at least 5 degrees of ankle dorsiflexion and 10 degrees of ankle plantarflexion with the affected ankle;
- no excessive spasticity;
- no severe contracture (passive range of motion ≥ 10 degrees for ankle dorsiflexion and ≥ 20 degrees for ankle plantarflexion) in the affected leg;
- mild-to moderate disability;
- can walk independently or under supervision without assistance;
- corrected far vision ≥ 0.8 (Landolt C test) and uncorrected near vision ≥ 0.04 (Comprehensive Color Blindness Checklist.)
Key Trial Info
Start Date :
July 9 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06556043
Start Date
July 9 2024
End Date
July 31 2026
Last Update
August 19 2024
Active Locations (1)
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1
School and Graduate Institute of Physical Therapy, National Taiwan University
Taipei, Taiwan, 100