Status:
RECRUITING
A Study Comparing Cancer Imaging Approaches in People With Lobular Breast Cancer
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Conditions:
Breast Cancer
Lobular Breast Carcinoma
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study to compare two types of cancer imaging scans to see which is better at detecting and monitoring metastatic ILC. This study will compare PET/CT (positron emission tomography/c...
Eligibility Criteria
Inclusion
- Adult patient \> 18 years old
- Biopsy-proven metastatic ILC
- Confirmed ER+ breast cancer from either primary tumor or metastatic biopsy (ER receptor percent staining ≥ 10% of tumor cells by IHC)
- HER2-negative per ASCO/CAP
- ECOG Performance Status Score of 0, 1 or 2.
- Patient can have received up to 2 lines of therapy in the metastatic setting
- Life expectancy of at least 12 months
Exclusion
- Low ER expression defined as ER \<10% of tumor cells by IHC
- Patients who have been on adjuvant ER-blocking endocrine therapy with SERM or SERD without an 8- and 24-weeks washout, respectively. (The use of aromatase inhibitors or ovarian suppression is permitted given that they do not block estrogen receptors).
- Pregnancy or lactation or parturient or nursing mother
- Patient presents with any other clinically active, serious, life-threatening disease, medical, or psychiatric condition, and/or who has a life expectancy of \<12 months, or for whom study participation may compromise their management; and/or a patient who the investigator judges to be unsuitable for participation in the study for any reason.
Key Trial Info
Start Date :
August 13 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 13 2027
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06557148
Start Date
August 13 2024
End Date
August 13 2027
Last Update
August 24 2025
Active Locations (7)
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1
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
2
Memorial Sloan Kettering Monmouth (Limited protocol activities)
Middletown, New Jersey, United States, 07748
3
Memorial Sloan Kettering Bergen (All Protocol Activities)
Montvale, New Jersey, United States, 07645
4
Memorial Sloan Kettering Suffolk-Commack (All protocol activity)
Commack, New York, United States, 11725