Status:
RECRUITING
Single-Cell Sequencing Analysis of Radiation Pneumonitis Signals In Patients Treated For Cancer With Radiotherapy
Lead Sponsor:
NHS Lothian
Conditions:
Radiation Pneumonitis
Eligibility:
All Genders
18+ years
Brief Summary
Patients with signs of radiation induced lung inflammation, who are referred for a clinical bronchoscopy for investigation, will have a sample sent for single cell sequencing. This is a novel techniqu...
Detailed Description
Lung cancer is the third most common cancer in the UK with around 48,500 people diagnosed with the condition each year. Unfortunately, despite significant progress in treatment options and their deliv...
Eligibility Criteria
Inclusion
- Age over 18 years
- Patient has received thoracic radiotherapy and has clinical or radiological features in fitting with a diagnosis of Radiation Pneumonitis (onset one to four months post-RT with breathlessness, especially exertional, cough, chest discomfort, which is persistent over weeks, a chest x-ray \[CXR\] may demonstrate patchy or widespread opacification although can be normal.)
- Must be ambulant, oxygen independent with SpO2 \>92% on air and haemodynamically stable to be considered safe for a bronchoscopy.
- Willing to undergo and likely able to tolerate bronchoscopy, ie. Can lie flat without compromising ventilation, and able to consent to the ELFMAN Protocol and SPITFIRE trial.
Exclusion
- Contraindication to bronchoscopy, ie. Previously not tolerated, unable to lie flat, Sp02 \<92% on air
- Patient requires admission or oxygen dependant
- Test positive for Covid-19 within the preceding six weeks to enrolment
Key Trial Info
Start Date :
October 25 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT06557343
Start Date
October 25 2024
End Date
December 1 2026
Last Update
January 9 2026
Active Locations (3)
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1
Centre for Information Research, University of Edinburgh
Edinburgh, United Kingdom, EH16 4UU
2
Henderson Lab
Edinburgh, United Kingdom, EH16 4UU
3
Edinburgh Cancer Centre
Edinburgh, United Kingdom, EH4 2XU