Status:
RECRUITING
Diagnosis of Graft Pathology by TruGraf
Lead Sponsor:
University Health Network, Toronto
Collaborating Sponsors:
Transplant Genomics, Inc.
Conditions:
Acute Graft Rejection
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this observational study is to to identify different causes of liver diseases or damage in liver transplant patients and develop a machine learning algorithm as a non-invasive tool leverag...
Detailed Description
Given the significant investment of healthcare resources into transplantation, it is critical to identify recipients with graft pathologies such as Acute Cellular Rejection (ACR), NASH, cholestasis, e...
Eligibility Criteria
Inclusion
- . Single-organ Liver transplant recipients
- Male or female, age \> 18 years at the time of signing informed consent.
- Willing and able to provide informed consent.
- Patients will be undergoing liver graft biopsy (for any reason), or have had a liver biopsy within 48 hours of consent.
Exclusion
- Repeat transplant
- Recipient of multi organ transplantation
- Any treatment for graft rejection such as IV steroids has been given before biopsy.
- Targeted biopsies for diagnosis of malignancy.
Key Trial Info
Start Date :
July 20 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2027
Estimated Enrollment :
471 Patients enrolled
Trial Details
Trial ID
NCT06557564
Start Date
July 20 2024
End Date
December 30 2027
Last Update
August 16 2024
Active Locations (1)
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1
Toronto General Hospital -UHN
Toronto, Ontario, Canada, M5G 2N2