Status:
RECRUITING
Exploring the Characteristics of Epileptogenic Foci in Drug-Resistant Epilepsy Based on Multimodal Imaging Technology
Lead Sponsor:
Xijing Hospital
Conditions:
Drug Resistant Epilepsy
Magnetic Resonance Imaging
Eligibility:
All Genders
18-65 years
Brief Summary
Using multimodal imaging technology, this study aims to explore the characteristics of epileptogenic foci in patients with drug-resistant epilepsy and identify key network nodes (such as central nodes...
Detailed Description
This study is a prospective observational cohort study. It prospectively recruited 50 patients with drug-resistant epilepsy from the Epilepsy Center of the Department of Neurology at Xijing Hospital, ...
Eligibility Criteria
Inclusion
- Aged ≥18 years old;
- Meet the 2010 International League Against Epilepsy (ILAE) diagnostic criteria for drug-resistant epilepsy;
- Duration of epilepsy ≥2 years, with an average seizure frequency of ≥2 times per month in the 3 months prior to enrollment;
- Adequate intake of two or more anti-epileptic drugs, with no intervention in the treatment plan during the trial period;
- Capable of cooperating to complete treatment and related examination items; The patient and family fully understand and voluntarily sign the informed consent form.
Exclusion
- In a state of continuous epileptic seizures;
- Complicated with severe infections, cerebrovascular diseases, malignant tumors, and other diseases, accompanied by severe dysfunction of the heart, liver, kidney, or other organs, or with mental disorders, or with uncorrectable hyperglycemia, or 3.patients on long-term use of corticosteroid medications;
- Pregnant or lactating women; 5.Contraindications for PET, MR, EEG examinations; 6.Patients with examinations (with ferromagnetic metal implants in the body; high fever); 7.Participating in other clinical trials at the same time; 8.The patient or family withdraws the informed consent form.
Key Trial Info
Start Date :
June 11 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06557720
Start Date
June 11 2024
End Date
August 1 2027
Last Update
June 25 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Xijing Hospital of Air Force Military Medical University
Xi'an, China