Status:
ACTIVE_NOT_RECRUITING
Effect of L. Plantarum Probiotic Supplementation on Broccoli Sulforaphane Bioavailability: Randomised Double-blind Placebo-controlled Crossover Study
Lead Sponsor:
University of Exeter
Collaborating Sponsors:
The University of Queensland
PepsiCo, Inc.
Conditions:
Nutrition, Healthy
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Broccoli has the precursor of an active compound (sulforaphane) that has shown a wide range of health promoting benefits. Sulforaphane formation depends on the conversion of glucoraphanin (precursor) ...
Detailed Description
Brassicas (i.e. broccoli, kale, cabbage) are a group of edible plants that contain a phytochemical called glucoraphanin that upon enzymatic hydrolysis forms the bioactive form sulforaphane. Sulforapha...
Eligibility Criteria
Inclusion
- healthy adults (male and female)
- age range of 18-65 years
- BMI range of 18-30 kg/m2
Exclusion
- have been on a course of antibiotics within the period of the past 3 months.
- have allergies or intolerance towards probiotic substances or broccoli used in the study and/or food intolerances associated with gastrointestinal upset.
- have been taking pre- or probiotics supplements regularly during the last month prior (this does not include foods containing probiotics and/or prebiotics foods)
- are following any restricting diet (e.g., vegan, FODMAP, etc.).
- have a gastrointestinal inflammatory condition (e.g., irritable bowel syndrome, inflammatory bowel diseases, coeliac diseases, constipation, etc.).
- have a medical condition or take medication for any heart, endocrine, or metabolic condition, such as high blood pressure, high cholesterol, insulin resistance, or diabetes, or autoimmune disease.
- are a pregnant and/or breastfeeding.
Key Trial Info
Start Date :
October 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT06561893
Start Date
October 1 2024
End Date
January 1 2026
Last Update
March 20 2025
Active Locations (2)
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1
The Department of Public Health and Sport Sciences, University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter
Exeter, Devon, United Kingdom, EX1 2 LU
2
Richard's Building, St Luke's Campus
Exeter, Devon, United Kingdom, EX2 4TA