Status:
RECRUITING
Online Adaptive Radiotherapy for Cervical Cancer
Lead Sponsor:
Peking Union Medical College Hospital
Collaborating Sponsors:
The First Affiliated Hospital of Jiangsu University
Zhongnan Hospital
Conditions:
Cervical Cancer
Eligibility:
FEMALE
18-80 years
Phase:
PHASE2
Brief Summary
This study aims to evaluate the clinical efficacy and safety of online adaptive radiotherapy for cervical cancer patients received radical radiotherapy. By comparing with image-guided radiotherapy, th...
Eligibility Criteria
Inclusion
- 18-80 years old;
- Pathologically confirmed diagnosis of cervical cancer and pathological type of cervical squamous carcinoma;
- 2018 FIGO Stage Ib3, II, IIIB and IIIC1
- Proposed radical pelvic radiotherapy + concurrent sensitizing chemotherapy (platinum-based (cisplatin 30-40mg/m2 or carboplatin alone), starting concurrently in the first week, ≥5 courses)
- ECOG score 0-2
- Life expectancy greater than 6 months
- Ability to remain lying down for more than 30 minutes
- Patients were fully voluntary and autonomous and co-operated in signing the study informed consent form
- Complete blood count and basal metabolic indexes within 14 days before enrolment must meet the following requirements: NEUT ≥ 1.5\*109/L, HGB ≥ 60g/L, platelets ≥ 100×109/, blood creatinine \<1.5 mg/dL. AST and ALT are within 2 times the upper limit of normal
- Must complete baseline assessments and investigations required before treatment before enrolment
- be eligible for regular follow-up
Exclusion
- Have received radiotherapy or chemotherapy in the past
- Have undergone radical surgery for cervical cancer
- Have a previous history of malignant tumor
- Pregnant or lactating women
- Presence of other serious co-morbidities such as poorly controlled cardiovascular, urinary, digestive, respiratory, hematological and central nervous system diseases.
Key Trial Info
Start Date :
September 5 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
124 Patients enrolled
Trial Details
Trial ID
NCT06562166
Start Date
September 5 2024
End Date
December 1 2028
Last Update
January 8 2026
Active Locations (1)
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1
Peking union medical college hospital
Beijing, China, 100730