Status:
RECRUITING
STunning in Acute Myocardial Infarction - BAS
Lead Sponsor:
Vastra Gotaland Region
Conditions:
Myocardial Infarct
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The objective of this trial is to examine the effect of immediate versus late administration of beta blockers, angiotensin converting enzyme inhibitors (ACEI), and sodium/glucose cotransporter 2 (SGLT...
Detailed Description
Left ventricular (LV) remodeling after ST-elevation myocardial infarction (STEMI) is associated with poor outcomes, but the mechanisms underlying adverse LV remodeling are poorly understood. It is als...
Eligibility Criteria
Inclusion
- Patients with STEMI who undergo primary PCI within 6 hours of symptom onset (Excluding prodromal symptoms)
- Informed consent
Exclusion
- Killip class ≥ 3
- Chronic kidney disease with GFR \< 25 ml/min/1.73 m2
- Pre-existing non-reversible cardiac dysfunction or heart failure
- Current treatment with any beta blocker, RAAS inhibitor or SGLT2 inhibitor
- Absolute or relative contraindication to any one of the study drugs that confers a risk of patient safety if the patient participates in the trial and adheres to the protocol-specified recommendations, per the assessment of the treating physician
- Life expectancy less than one year
- Pregnancy or women of childbearing potential who is not sterilized or is not using a medically accepted form of contraception
Key Trial Info
Start Date :
January 6 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06562582
Start Date
January 6 2025
End Date
December 31 2027
Last Update
June 27 2025
Active Locations (1)
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1
Sahlgrenska University Hospital
Gothenburg, Sweden, 41345