Status:
UNKNOWN
Implication of Cognitive Reserve in Non-pharmacological Intervention Outcomes
Lead Sponsor:
Masaryk University
Conditions:
Aging
Mild Cognitive Impairment
Eligibility:
All Genders
60-75 years
Phase:
NA
Brief Summary
Cognitive reserve (CR) is defined as the gradual accumulation of neural resources and their adaptability (i.e., efficiency, capacity, flexibility) due to genetic and/or lifelong environmental factors ...
Detailed Description
A novel interventional approach is proposed for studying cognitive reserve (CR) using dynamic biomarkers, including: Neuromelanin-sensitive MRI sequences to evaluate signal intensity of the locus coe...
Eligibility Criteria
Inclusion
- Intact cognitive performance as assessed by cognitive evaluation.
- Subjects with possible or probable mild cognitive impairment with Lewy bodies (MCI-LB).
Exclusion
- Presence of dementia as assessed by a cognitive test battery and evaluation of daily activities.
- Any major psychiatric disorder. History of neurological disease affecting the central nervous system (e.g., tumor, epilepsy, stroke, etc.).
- Severe or repeated head injury. Non-compensated internal or oncological disease. MRI-incompatible metal in the body (e.g., pacemaker). Left-handedness.
Key Trial Info
Start Date :
May 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT06563453
Start Date
May 1 2021
End Date
December 31 2024
Last Update
August 28 2024
Active Locations (1)
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1
CEITEC Masaryk University
Brno, Czechia, 62500