Status:
NOT_YET_RECRUITING
To Explore the Functional Connectivity Pattern of Cortical Swallowing Network in the Oral Phase of Post-stroke Dysphagia Based on Dynamic Causal Modelling
Lead Sponsor:
Fujian University of Traditional Chinese Medicine
Collaborating Sponsors:
Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science
Conditions:
Dysphagia After Stroke
Cortical Swallowing Network
Eligibility:
All Genders
18-80 years
Brief Summary
Swallowing activity in the oral phase is regulated by the cortical swallowing network, and the functional connectivity pattern of the cortical swallowing network is related to swallowing activity. The...
Detailed Description
Swallowing is a complex movement consisting of sequential and ordered activation of swallowing muscles interconnected cortical areas that facilitate the complex communication of sensory inputs and mot...
Eligibility Criteria
Inclusion
- Inclusion criteria of patients with post-stroke oral dysphagia:
- Patients with dysphagia after first stroke, meeting the diagnostic criteria of stroke, and confirmed by brain CT or brain MRI;
- Oral dysphagia caused by stroke;
- FOIS level ≤ 5; WST level ≥3;
- Those who can understand and carry out the simple instructions of the treatment staff and are willing to accept the examination and treatment;
- Clear consciousness and stable vital signs;
- Patients in the recovery stage with stroke course and dysphagia duration between 0 and 6 months;
- Right-handed;
- Voluntary participants with informed consent.
- Inclusion criteria of patients without dysphagia after stroke:
- Patients with first-ever stroke, meeting the diagnostic criteria of stroke, and confirmed by brain CT or brain MRI;
- No dysphagia, FOIS level =7; WST level =1;
- Those who can understand and carry out the simple instructions of the treatment staff and are willing to accept the examination and treatment;
- Clear consciousness and stable vital signs;
- Patients in the recovery stage with stroke duration between 0 and 6 months;
- Right-handed;
- Voluntary participants with informed consent.
- Inclusion criteria of healthy control group:
- Normal cognitive function and swallowing function, FOIS level =7; WST level =1;
- Gender and age matched with patients with dysphagia in the oral phase after stroke;
- Right-handed;
- Voluntary participants with informed consent.
Exclusion
- Dysphagia not caused by stroke or non-oral dysphagia;
- History of cerebral trauma, stroke, brain tumor, cerebrovascular, intracranial infection, Parkinson's disease, epilepsy, or other neurological or psychiatric diseases;
- Symptoms of severe aphasia, neglect, visual field defect and other cortical lesions; Patients with severe cognitive impairment or depression;
- Taking or within 2 weeks of taking drugs that affect the nervous system or psychoses;
- Patients with metal implants and/or spatial claustrophobia who are not suitable for MRI scanning;
- Visual/hearing disorders affecting training and assessment;
- Persons who are participating in other research trials that may influence the results of this study.
Key Trial Info
Start Date :
August 20 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2025
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT06564688
Start Date
August 20 2024
End Date
July 1 2025
Last Update
August 21 2024
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