Status:
NOT_YET_RECRUITING
Preoperative Oral Heptaminol Hydrochloride in Preventing Hypotension After Spinal Anesthesia
Lead Sponsor:
Cairo University
Conditions:
Hypotension After Spinal Anesthesia
Eligibility:
All Genders
18-50 years
Phase:
PHASE3
Brief Summary
Methodologies and approaches have been implemented with differing degrees of success to prevent neuraxial hypotension. Currently utilized approaches to prevent hypotension during spinal anesthetic adm...
Eligibility Criteria
Inclusion
- Age from 18 to 50 years old.
- Both sexes.
- American Society of Anesthesiologists (ASA) physical status I-II.
- Undergoing elective orthopedic lower limb operations with a tourniquet or plastic surgeries under spinal anesthesia.
Exclusion
- Patient refusal.
- History of hypertension, cardiovascular \[disorders of the heart and blood vessels and including coronary heart disease, rheumatic heart disease and other conditions\], and cerebrovascular diseases \[conditions that affect blood flow and the blood vessels in the brain. Problems with blood flow may occur from blood vessel narrowing (stenosis), clot formation (thrombosis), artery blockage (embolism), or blood vessel rupture (hemorrhage)\].
- Baseline SBP \>160 mm Hg before administration of the drug.
- Any contraindications to spinal anesthesia such as coagulopathy, local skin infection, swelling, trauma, or deformity.
- Medical conditions, which release vasoconstrictors such as pheochromocytoma.
- Patients taking vasoconstrictors or uncorrected tachyarrhythmia.
- History of drug allergy.
- Psychiatric, neuromuscular disorder, major systemic diseases.
- Pregnancy or lactating women.
- Inadequate effect of spinal anesthesia or supplemented with other types of anesthesia.
Key Trial Info
Start Date :
August 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2025
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT06564935
Start Date
August 1 2024
End Date
March 1 2025
Last Update
August 21 2024
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