Status:
ACTIVE_NOT_RECRUITING
A Study to Evaluate Corneal Endothelial Cell Density (ECD) in Subjects With Dry Eye Disease (DED) Administering Miebo® (Perfluorohexyloctane Ophthalmic Solution) for 12 Months.
Lead Sponsor:
Bausch & Lomb Incorporated
Conditions:
Dry Eye
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
A Randomized, Multicenter, Double-Masked, Saline-Controlled Trial to Evaluate Corneal Endothelial Cell Density in Subjects With Dry Eye Disease Administering Miebo® (Perfluorohexyloctane Ophthalmic So...
Eligibility Criteria
Inclusion
- Be at least 18 years of age at the time of consent.
- Have a self-reported history of DED in both eyes (OU) for at least 6 months prior to Visit 1 (Screening/Baseline)
- Have a total corneal fluorescein staining score (tCFS) score \>2 in both eyes
- Have an Ocular Surface Disease Index (OSDI) score \>17
- Have a baseline ECD ≥1750 cells/mm2 in each eye
- Provide written informed consent
- Be able and willing to follow instructions, including participation in all trial assessments and visits
- If a contact lens wearer, be willing to discontinue contact lens use during and for 30 minutes following instillation of investigational drug and during study visits
Exclusion
- Be at least 18 years of age at the time of consent.
- Have a self-reported history of DED in both eyes (OU) for at least 6 months prior to Visit 1 (Screening/Baseline)
- Have a total corneal fluorescein staining score (tCFS) score \>2 in both eyes
- Have an Ocular Surface Disease Index (OSDI) score \>17
- Have a baseline ECD ≥1750 cells/mm2 in each eye
- Provide written informed consent
- Be able and willing to follow instructions, including participation in all trial assessments and visits
- If a contact lens wearer, be willing to discontinue contact lens use during and for 30 minutes following instillation of investigational drug and during study visits
- Have any clinically significant ocular surface slit lamp findings and/or in the opinion of the Investigator have any findings that may interfere with trial parameters in either eye
- Have an ocular or periocular malignancy in either eye
- Have a history of herpetic keratitis in either eye
- Have any planned ocular and/or lid surgeries in either eye during the course of the study
- Have a known allergy and/or sensitivity to the IP
- Have a history of ocular laser surgery in either eye within 3 months (90 days) prior to Visit 1 (Screening/Baseline)
- Have a history of incisional ocular surgery or severe trauma in either eye within 3 months (90 days) prior to Visit 1 (Screening/Baseline)
- Have high contrast best-corrected visual acuity equal to or worse than logMAR +0.7 (Snellen equivalent score of 20/100 or worse) as assessed by Early Treatment Diabetic Retinopathy Study (ETDRS) scale in either eye, obtained under bright room lighting
- Be a woman who is pregnant, nursing or planning a pregnancy during the course of the study
- Be a woman of childbearing potential who is unwilling to submit to a urine pregnancy test. Non-childbearing potential is defined as a woman who is permanently sterilized (eg, has had a hysterectomy or bilateral tubal ligation or bilateral oophorectomy) or is postmenopausal (without menses for 12 consecutive months).
- Be a woman of childbearing potential who is not using an acceptable method of birth control. Acceptable methods of contraception include hormonal - oral, implantable, injectable, or transdermal - contraceptives; mechanical contraception - spermicide in conjunction with a barrier such as a diaphragm or condom; intrauterine device; or surgical sterilization of partner. For non-sexually active females, abstinence may be regarded as an adequate method of birth control; however, the subject must agree to use adequate birth control as defined above for the remainder of the study if she becomes sexually active during the trial.
- Be currently enrolled in an investigational drug or device trial or plan to enroll during the course of the study
- Have a condition or be in a situation that the Investigator believes may put the subject at significant risk, may confound the study results, or may interfere significantly with the subject's participation in the study
Key Trial Info
Start Date :
July 31 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2025
Estimated Enrollment :
216 Patients enrolled
Trial Details
Trial ID
NCT06565650
Start Date
July 31 2024
End Date
November 1 2025
Last Update
December 17 2024
Active Locations (12)
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1
Site 101
Glendale, California, United States, 91204
2
Site 112
Murrieta, California, United States, 92562
3
Site 102
Newport Beach, California, United States, 92663
4
Site 109
Rancho Cordova, California, United States, 95670