Status:
RECRUITING
DPA-714 and FDG PET/MRI in Depression
Lead Sponsor:
The First Affiliated Hospital of Dalian Medical University
Conditions:
Depression
Eligibility:
All Genders
35-85 years
Phase:
NA
Brief Summary
Depression, a common psychological disorder, is characterized by persistent low mood, loss of interest, and anhedonia, leading to significant dysfunctions and a high suicide risk. Its pathogenesis rem...
Detailed Description
Depression is a common psychological disorder caused by various factors, characterized by significant and persistent low mood, loss of interest, and anhedonia as core symptoms, leading to physical, ps...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- For all groups :
- No alcohol or psychoactive substances such as coffee had been consumed in the 24 hours prior to the examination
- MMSE≥24 points，MOCA≥26 points
- No anti-infective drugs in the past 1 month, no cold, fever or other infection history in the past 2 weeks
- Patients with diabetes had fasting controlled below 9.0mmol/L before the examination
- Volunteer to participate in the study and sign the informed consent
- For Recurrent depression patients:
- Meet the Diagnostic criteria for recurrent major depressive disorder in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V)
- Age 35-85 years old, gender is not limited
- HAMD≥8 points
- For first episode depression Patients:
- Gender, age and education level were matched with the recurrent depression group
- Meet the Diagnostic criteria for the first episode of depressive disorder in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V)
- HAMD≥8 points
- For controls:
- Healthy people undergoing "DPA-714 or FDG imaging PET/MRI" physical examination in PET/CT room of our hospital
- Gender and education level were consistent with both the recurrent depression group and the first-episode depression group
- never used any psychotropic drugs
- HAMD\<8 points；HAMA\<7 points
- Exclusion Criteria(for all groups):
- Have a history of organic mental disorders or other mental disorders
- A family history of hereditary diseases
- Persons with mental retardation or dementia
- A history of psychoactive substance abuse
- Can not cooperate with/complete the psychological examination scale
- Previously found serious physical diseases (heart, brain, liver, lung and kidney)
- MRI contraindications, abnormalities found in head CT or MRI
- A history of drug or alcohol abuse
- Have a history of metabolic diseases such as hyperthyroidism, hypothyroidism,and rheumatic diseases
- are in the state of pregnancy or breastfeeding
Exclusion
Key Trial Info
Start Date :
August 23 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT06565936
Start Date
August 23 2024
End Date
December 1 2026
Last Update
November 12 2024
Active Locations (1)
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1
The First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, China, 116000