Status:
RECRUITING
Leucine Supplementation Strategies to Enhance Muscle Anabolic Responses in Older Age
Lead Sponsor:
University of Nottingham
Conditions:
Muscle Protein Synthesis
Eligibility:
MALE
65-75 years
Phase:
NA
Brief Summary
Sarcopenia describes the progressive decline of muscle mass and strength with advancing age and is associated with increased frailty and morbidity, however we do not currently have an effective treatm...
Eligibility Criteria
Inclusion
- Male, 65-75 years of age
- BMI 18-28 kg/m2
- Non smoker
- Not performing regular resistance type exercise
- Participant is willing and able to give informed consent for participation in the study
Exclusion
- A BMI \<18 or \>28 kg·m-2
- Active cardiovascular disease: uncontrolled hypertension (BP \> 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt or recent cardiac event
- Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial)
- Respiratory disease including pulmonary hypertension or chronic obstructive pulmonary disease (COPD)
- Metabolic disease: hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, types 1 or 2 diabetes (treated and untreated), inborn/ congenital errors of metabolism (e.g. phenylketonuria (PKU), galactosaemia)
- Active inflammatory bowel disease
- Acute infection
- Acute or chronic renal disease
- Malignancy (or history of malignancy with 5 y)
- Recent steroid treatment (within 6 mo), or hormone replacement therapy
- Coagulopathy
- Musculoskeletal or neurological disorders
- Known allergies to any of the product ingredients
- Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance
Key Trial Info
Start Date :
August 5 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 5 2026
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT06567665
Start Date
August 5 2024
End Date
August 5 2026
Last Update
August 23 2024
Active Locations (1)
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1
University of Nottingham
Nottingham, Nottinghamshire, United Kingdom, NG7 2UH