Status:
ENROLLING_BY_INVITATION
Endoscopic Gastroenterostomy Versus Surgical Gastrojejunostomy
Lead Sponsor:
Vanderbilt University Medical Center
Conditions:
Malignant Gastric Outlet Obstruction
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Recent comparative data suggest that EUS gastroenterostomy offers more durable patency than enteral stents for treatment of malignant GOO, leading some endoscopists to suggest that EUS gastroenterosto...
Eligibility Criteria
Inclusion
- Age 18 years or older
- Able to provide informed consent
- Biopsy-proven cancer
- Cancer without surgical resection as a curative treatment option
- Clinical and radiographic presentation consistent with primary or metastatic tumor causing foregut obstruction at the level of the pylorus and/or duodenum
Exclusion
- Age \<18 years
- Pregnancy
- Unable to provide informed consent
- White Blood Count \< 3,000
- Absolute Neutrophil Count \< 1,500
- International normalized ratio \> 1.6
- Platelet count \< 100,000
- Cancer with surgical resection as a curative treatment option
- Surgically altered foregut anatomy
- Multifocal intestinal obstruction
- Abdominal ascites prohibitive of surgical candidacy
- Abdominal wall mesh prohibitive of surgical candidacy
- Child's Class B or C cirrhosis
- Gastroesophageal varices or known portal hypertension
- Body mass index \>40
Key Trial Info
Start Date :
August 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2027
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT06567691
Start Date
August 1 2025
End Date
January 1 2027
Last Update
August 26 2025
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212