Status:
RECRUITING
Beta-1 Adrenergic Inhibition to Reduce Cardiac Injury and Inflammation After Subarachnoid Hemorrhage (BADCATS)
Lead Sponsor:
Madeleine Puissant
Collaborating Sponsors:
MaineHealth
Conditions:
Non-Traumatic Subarachnoid Hemorrhage
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
To determine the effect of early metoprolol administration after non-traumatic subarachnoid hemorrhage (SAH).
Detailed Description
To determine the effect of early metoprolol administration after non-traumatic subarachnoid hemorrhage (SAH) on the brain and cardiac tissue damage and inflammation, we will conduct a pilot randomized...
Eligibility Criteria
Inclusion
- \>18 years of age
- Neuro-imaging confirmed non-traumatic subarachnoid hemorrhage
Exclusion
- Traumatic cause of subarachnoid hemorrhage (e.g. fall, motor vehicle accident, other blunt trauma) as this is a different mechanism of hemorrhage.
- Other forms of traumatic or non-traumatic intracranial bleed including intracerebral hemorrhage (ICH), subdural hemorrhage, epidural hemorrhage
- Pregnancy (as the study medication, metoprolol, has FDA Pregnancy Category C rating)
- Unstable vital signs not amenable to beta-1 adrenergic receptor inhibitor (B1ARi) administration including:
- Systolic blood pressure \< 80 mmHg not stabilized on vasopressor medications
- Heart rate \< 50 bpm associated with hypotension
- Patients requiring vasopressor agents due to hypotension (SBP \<80 mmHg)
- Other vital sign exclusion at the discretion of the treatment team
- Previous history of severe heart failure (Stage C or D Heart Failure and/or NYHA Class III or IV)
- Patient or legally authorized representative unwilling to provide informed consent
Key Trial Info
Start Date :
September 23 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2029
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06569212
Start Date
September 23 2024
End Date
September 1 2029
Last Update
November 26 2024
Active Locations (1)
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1
MaineHealth
Portland, Maine, United States, 04012