Status:
RECRUITING
Tissue Sodium Quantification in Patients With Primary Aldosteronism: See Sodium to Treat
Lead Sponsor:
Jens Titze
Collaborating Sponsors:
Changi General Hospital
Singapore General Hospital
Conditions:
Hypertension
Primary Aldosteronism
Eligibility:
All Genders
21-70 years
Brief Summary
The study aims to provide quantitative facts on the pathophysiological changes in tissue Na+ content during Na+/K+ redistribution disorders in patients with PA in response to standard therapy. The inv...
Detailed Description
Arterial hypertension is a major modifiable cardiovascular risk factor along with diabetes mellitus. Hypertension due to autonomous elevation in aldosterone production (Primary Aldosteronism; PA) is n...
Eligibility Criteria
Inclusion
- Age 21-70 years, with arterial hypertension or suspected to have primary aldosteronism based on Endocrine Society Guidelines.
- Male and female patients older than 21 years.
- Willingness to participate and ability to provide informed consent.
Exclusion
- Patients with exclusion criteria for the MRI, such as:
- implanted devices (surgical clips, heart pacemakers or defibrillators, cochlear implants)
- iron-based tattoos
- any other pieces of metal or devices that are not MR-Safe anywhere in the body
- patients who exhibit noticeable anxiety and/or claustrophobia into the MRI scanner
- pregnancy
- Diagnosis of heart failure NYHA classes III and IV
- Impaired renal function with eGFR\<30 ml/min or proteinuria \> 1 g/24h
- Liver disease with cirrhosis (Child-Pugh class C) or hypoalbuminemia
- Muscular dystrophies
- Patients with active cancer or severe comorbid conditions likely to compromise survival or study participation
- Unwillingness or other inability to cooperate
Key Trial Info
Start Date :
December 27 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 31 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06569589
Start Date
December 27 2023
End Date
August 31 2026
Last Update
June 6 2025
Active Locations (4)
Enter a location and click search to find clinical trials sorted by distance.
1
Singapore General Hospital
Singapore, Singapore, 169608
2
Duke NUS Medical School
Singapore, Singapore, 169857
3
Changi General Hospital
Singapore, Singapore, 529889
4
Sengkang General Hospital
Singapore, Singapore, 544886