Status:
RECRUITING
Growth Hormone Resistance of Beta-cells
Lead Sponsor:
University of Missouri-Columbia
Conditions:
Gestational Diabetes
Obesity
Eligibility:
FEMALE
18-45 years
Brief Summary
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal his...
Eligibility Criteria
Inclusion
- Singleton, full term pregnancy within the past 5 years
- Hemoglobin HbA1c ≤5.6% and fasting blood glucose \<100 mg/dl
- Body mass index ≥30.0 kg/m2 and \<45.0 kg/m2, because the majority of women with GDM have overweight/obesity
- Group specific inclusion criteria:
- Gestational Diabetes Group: History of gestational diabetes in the most recent pregnancy
- Control Group: no history of gestational diabetes
Exclusion
- Pregnant, planning to become pregnant during the study, or breastfeeding
- Current diagnosis or history of type 1 or type 2 diabetes
- Use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists)
- History of bariatric surgery
- Known hypothyroidism or use of thyroid medications
- History of intracranial hypertension, including papilledema, or a condition that increases the risk of developing intracranial hypertension, such as Turner Syndrome, Prader-Willi Syndrome, or renal impairment
- Current cancer or cancer that has been in remission less than 5 years
- First degree relative with diabetes diagnosis
- Evidence of significant anemia or significant end organ dysfunction (e.g., liver, kidney, heart disease)
- Alcohol use disorder, use of controlled substances, or smoking \>2 cigarettes per day
- Greater than 3% weight loss within three months of screening or engaged in regular (≥3 days per week), continuous moderate- or high-intensity exercise of ≥30 min duration
- Mentally disabled persons, prisoners, and persons with inability to grant voluntary informed consent
Key Trial Info
Start Date :
October 22 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2030
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06571487
Start Date
October 22 2025
End Date
September 1 2030
Last Update
November 14 2025
Active Locations (1)
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1
University of Missouri School of Medicine
Columbia, Missouri, United States, 65212