Status:
ENROLLING_BY_INVITATION
Simulation-informed Modelling and Personalized Evaluation (SIMPLE) in Ageing Populations
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Neurodegenerative Diseases
Aging
Eligibility:
All Genders
50-90 years
Brief Summary
Multimodal magnetic resonance imaging (MRI), detecting brain structural and functional changes, has emerged as a powerful and promising technique to study individual's brain, as T1-weighted scans can ...
Detailed Description
The score of brain-PAD has threefold explanations: a. negative score representing decelerated brain ageing (brain age\<chronological age); b. positive score representing accelerated brain ageing (brai...
Eligibility Criteria
Inclusion
- Chinese old adults are the ones who are over 60 years of chronological age.
- Sleep disturbance: individual's subjective sleep quality is assessed using the Pittsburgh Sleep Quality Index (PSQI) with a total score \>5.
Exclusion
- History of bipolar disorders or psychosis.
- History of major neurological deficits, including stroke, transient ischemic attack or brain tumor.
- Unable to participant magnetic resonance imaging (MRI) scanning.
Key Trial Info
Start Date :
January 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT06572332
Start Date
January 1 2025
End Date
December 31 2026
Last Update
January 14 2025
Active Locations (1)
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1
Tai Po Hospital
Hong Kong, Hong Kong, 100000