Status:
RECRUITING
USPIO Enhanced MR Imaging in CNS Tumours (UMIC)
Lead Sponsor:
Northern Care Alliance NHS Foundation Trust
Conditions:
Vestibular Schwannoma
Glioma, Astrocytic
Eligibility:
All Genders
16-100 years
Phase:
NA
Brief Summary
The immune response or inflammation is known to be a key driver of progression and growth in many solid tumours. Inflammatory cells called macrophages are present in high numbers in many brain tumours...
Eligibility Criteria
Inclusion
- Be at least 16 years old
- Have a CNS tumour suspected to be one of the defined histological types (vestibular scwhannoma or low grade glioma)
- Be able to lie still for up to 1 hour comfortably
- Opinion of the treating clinician is that the patient will be able to successfully complete the research imaging protocol.
Exclusion
- Life expectancy less than 1 year
- Previous CNS radiotherapy/ stereotactic radiosurgery (SRS)
- Females who are pregnant/ breastfeeding
- Patients with an eGFR \< 30ml/min
- Patients with known and documented history of iron overload/haemosiderosis/ haemochromatosis
- Patients with immune or inflammatory conditions e.g. systemic lupus erythematous, rheumatoid arthritis
- Patients with absolute (e.g. pacemaker) and relative (anxiety or claustrophobia) contraindications to MR scanning
- Patients with a history of allergic reaction to iron or dextran
- Patients with a history of allergic reaction to gadolinium contrast agents, asthma or renal problems
- Patients who are unable to adequately understand verbal explanations or written information given in English.
Key Trial Info
Start Date :
April 26 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT06572475
Start Date
April 26 2024
End Date
December 31 2026
Last Update
August 27 2024
Active Locations (1)
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1
Salford Royal Hospital Northern Care Alliance NHS Foundation Trust
Salford, Greater Manchester, United Kingdom, M6 6HD