Status:
RECRUITING
Noninvasive Ventilation Breathing Test Guiding Weaning in Patients With Acute Hypoxic Respiratory Failure
Lead Sponsor:
West China Hospital
Collaborating Sponsors:
Sichuan University
Dazhou Central Hospital
Conditions:
Acute Hypoxic Respiratory Failure
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
SBT, as a routine extubation strategy for invasive mechanical ventilation, has been widely recognized. However, in recent years, studies have found that SBT may lead to delayed extubation, which has b...
Detailed Description
All the patients included will be randomly assigned to receive Non Invasive Ventilation Breathing Test protocol or SBT protocol.
Eligibility Criteria
Inclusion
- Adult patients who have been admitted to the intensive care unit (ICU) with Acute Hypoxic Respiratory Failure. Oxygenation index less than 300mmHg, have undergone tracheal intubation, and are anticipated received invasive mechanical ventilation for more than 24 hours.
Exclusion
- • Age over 80 years,
- Pregnancy,
- Consciousness disorders or intracranial hypertension caused by various reasons,
- Neuromuscular disorders,
- Severe cardiac dysfunction (New York Heart Association Class III or IV, acute coronary syndrome or persistent ventricular tachycardia),
- Cardiogenic shock or after major cardiac surgery,
- Severe liver and kidney failure,
- Severe malnutrition,
- Injury to the upper airway or nose and face, making it impossible to wear a nose (face) mask,
- Severe agitation, Severe agitation, expected to be unable to cooperate with non-invasive mechanical ventilation.
Key Trial Info
Start Date :
March 20 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2024
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06574659
Start Date
March 20 2024
End Date
December 30 2024
Last Update
August 28 2024
Active Locations (1)
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1
West China Hospital,Sichuan University
Chengdu, Sichuan, China, 610041