Status:
NOT_YET_RECRUITING
Predicting Cerebral Palsy in Infants With White Matter Injury Using MRI
Lead Sponsor:
First Affiliated Hospital Xi'an Jiaotong University
Collaborating Sponsors:
The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
Shenzhen Children's Hospital
Conditions:
Cerebral Palsy
Periventricular White Matter Abnormalities
Eligibility:
All Genders
6-2 years
Brief Summary
The goal of this study is to determin the MRI features associated with cerebral palsy and to develop prediction models of pediatric disorders by combining MRI with artificial intelligence. The main q...
Detailed Description
Cerebral palsy (CP) is a common group of movement disorders that often results in disability in children. In the context of CP, the importance of early diagnosis is crucial, but current diagnostic mod...
Eligibility Criteria
Inclusion
- Infants and children at high risk of periventricular white matter injury (PVWMI) (gestational age \<35 weeks, birth weight \<2.6 kg, forceps-assisted delivery/fetal head attraction, Apgar score \<7, hypoglycaemia, sepsis, electrolyte disturbances, premature rupture of membranes);
- Those who underwent MRI at 6 months of age-2 years, including at least T1WI and T2WI sequences;
- Upon follow-up, the patient's clinical diagnosis: cerebral palsy, other diagnoses that did not develop into cerebral palsy, or inability to confirm the diagnosis).
Exclusion
- Incomplete MRI images or unreadable images due to motion artefacts;
- Incomplete neurobehavioural assessment data (including: gross motor function).
Key Trial Info
Start Date :
September 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT06575283
Start Date
September 1 2024
End Date
December 31 2025
Last Update
September 19 2024
Active Locations (1)
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1
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China