Status:
RECRUITING
THROmbinography in Pregnant Woman and in Vitro Action of Low Molecular Weight HEparin
Lead Sponsor:
University Hospital, Clermont-Ferrand
Conditions:
Pregnant Women
Venous Thromboembolic Disease
Eligibility:
FEMALE
18-55 years
Brief Summary
Pregnancy is associated with major changes affecting all satges of hemostasis. Certain procoagulant factors are increased, such as factors VII, VIII, IX, X, XII, fibrinogen and Von Willebrand factor. ...
Detailed Description
Pregnancy is considered a risk factor for venous thromboembolism (VTE), with deep vein thrombosis and pulmonary embolism the main causes of maternal morbidity and mortality. studies report a 5-fold in...
Eligibility Criteria
Inclusion
- Normal 1st trimester pregnancy
- Age \> 18
Exclusion
- Coagulation disease (Von Willebrand disease, known coagulation factor deficiency before pregnancy)
- VTE history
- First-degree family history of idiopathic VTE
- Known biological risk factor for thrombosis Inherited deficiencies in coagulation inhibitors (antithrombin, protein C, protein S) Factor V Leiden polymorphism Prothrombin gene 20210G\>A polymorphism Anti-phospholipid antibodies
- Current anticoagulant use (VKA, heparins, etc.)
- Gestational diabetes detected in the 1st trimester
- Pre-existing type 1 and type 2 diabetes
- History of pathological pregnancy Premature delivery Postpartum hemorrhage Preeclampsia
- Hepatopathy
- Obesity (BMI ≥ 30)
- Infections (HIV, HBV, HCV...)
- Autoimmune diseases
- Pregnancy resulting from in vitro fertilization protocol
- Multiple pregnancy
- Patient under guardianship, curatorship or safeguard of justice
- Patient not covered by a social security scheme
- Patient deprived of liberty
Key Trial Info
Start Date :
November 21 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06575309
Start Date
November 21 2024
End Date
May 1 2027
Last Update
November 26 2024
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
CHU de Clermont-Ferrand
Clermont-Ferrand, France, 63000
2
CHU Estaing
Clermont-Ferrand, France, 63003