Status:
RECRUITING
Effects of Neoadjuvant Therapy With Carboplatin, Paclitaxel Combined With Anti-PD-1 Drugs on Cognitive Function in Patients With Resectable Head and Neck Squamous Cell Carcinoma
Lead Sponsor:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Conditions:
Head and Neck Squamous Cell Carcinoma
Eligibility:
All Genders
18-80 years
Brief Summary
The goal of this observational study is to learn about the Effects of neoadjuvant therapy with carboplatin, paclitaxel combined with anti-PD-1 drugs on cognitive function in patients with resectable h...
Eligibility Criteria
Inclusion
- 1: The patient was diagnosed with head and neck squamous cell carcinoma (stage I-IVA), without treatment, and planned to undergo only surgical treatment or surgical treatment + chemotherapy and immunotherapy.
- 2: Can speak Chinese and have certain reading and writing skills
- 3: Healthy group: Dental inpatients with non-oral cancer, no history of neurological diseases, and no previous history of malignant tumors
Exclusion
- 1: Brain tumor, brain injury, or stroke at baseline or during follow-up
- 2: A history of stroke or a medical condition that puts you at high risk for future dementia or recurrence
- 3: Active mental illness or active narcotic drug use, including using alcohol more than 4 times per day or more than 4 times per week
- 4: Neurocognitive diseases that affect cognitive function, such as Parkinson's disease or Alzheimer's disease
- 5: History of drug-associated encephalopathy or brain infection
- 6: Patients who change their treatment plan during treatment
- 7: Patients who are currently taking or have taken antidepressants
Key Trial Info
Start Date :
August 23 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
306 Patients enrolled
Trial Details
Trial ID
NCT06576180
Start Date
August 23 2024
End Date
September 1 2026
Last Update
August 28 2024
Active Locations (1)
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1
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Guanzhou, Guangdong, China, 510000