Status:
RECRUITING
Osteosarcopenia in Axial Spondyloarthritis
Lead Sponsor:
Ankara University
Conditions:
Axial Spondyloarthritis
Ankylosing Spondylitis
Eligibility:
All Genders
18-65 years
Brief Summary
Axial spondyloarthritis is a chronic inflammatory disease affecting the spine, sacroiliac joints, entheses, and sometimes peripheral joints with a close link to HLAB27. Typical features include inflam...
Detailed Description
Ankylosing Spondylitis (AS) is a chronic inflammatory disease of unknown etiology that affects the spine, sacroiliac joints, entheses regions, and sometimes peripheral joints. Its typical findings inc...
Eligibility Criteria
Inclusion
- Patient group:
- Participants with a diagnosis of AxSpA: Participants with diagnosis of Ankylosing Spondylitis according to the modified New York criteria and participants with diagnosis of non-radiographic Spondyloarthritis (SpA) according to the Assessment of SpondyloArthritis International Society (ASAS) 2009 criteria.
- Aged 18-65 years
- Who gave consent to participate in the study
- Healthy control group:
- Age- and gender-matched healthy participants (age 18-65)
- Who gave consent to participate in the study
Exclusion
- Systemic high-dose steroid use (\>5mg/day of prednisone for more than 3 months)
- Possible other causes of secondary sarcopenia (uncontrolled diabetes, chronic heart failure, thyroid/parathyroid disease, chronic renal failure, chronic liver failure)
- Hand-related disorders/diseases that could affect the healthy assessment of grip strength
- Use of any medication that could potentially affect the bone metabolism (bisphosphonates, teriparatide, anticonvulsants, heparin, and anticoagulants)
- Psoriasis, inflammatory bowel disease
- Infection in the thigh area where ultrasonographic evaluation will be performed
- Body weight over 100 kg (contraindication to be positioned in the BMD device)
- Presence of malnutrition (individuals scoring 11 or below on the Mini Nutritional Assessment-Short Form (MNA))
Key Trial Info
Start Date :
September 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2025
Estimated Enrollment :
97 Patients enrolled
Trial Details
Trial ID
NCT06577350
Start Date
September 1 2023
End Date
April 1 2025
Last Update
August 29 2024
Active Locations (1)
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1
Ankara University Hospitals, Department of Physical Medicine and Rehabilitation
Ankara, Turkey (Türkiye), 06230