Status:
RECRUITING
End-Tidal Oxygen for Intubation in the Emergency Department
Lead Sponsor:
Sydney Local Health District
Conditions:
Critical Illness
Hypoxia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Rapid Sequence Intubation (RSI) is a high-risk procedure in the emergency department (ED). Patients are routinely preoxygenated (given supplemental oxygen) prior to RSI to prevent hypoxia during intub...
Detailed Description
BACKGROUND AND INTRODUCTION Rapid Sequence Intubation (RSI) is a common procedure in Emergency Departments (ED). However, it is a high-risk procedure and is associated with significant complications ...
Eligibility Criteria
Inclusion
- The patient is located in the ED resuscitation bay of the participating centre.
- The planned procedure is orotracheal intubation using a laryngoscope and RSI technique with preoxygenation for patients who are spontaneously breathing.
- The patient is deemed to be at a high risk of hypoxia during RSI as per the treating ED clinician, as defined by:
- Any patient requiring any form of oxygen therapy before preoxygenation.
- Any patient with respiratory pathology based on clinical or radiological findings. Including, but not limited to:
- Pneumonia, pulmonary oedema, acute respiratory distress syndrome (ARDS), aspiration, pulmonary contusion from trauma, infective exacerbations of known lung disease (e.g. asthma, pulmonary fibrosis, emphysema) or pulmonary embolism (PE)
- Any patient with high oxygen consumption. Including, but not limited to:
- Sepsis, Diabetic ketoacidosis, alcohol or drug withdrawal, seizures, thyrotoxicosis
- Any underlying patient condition that may predispose to hypoxemia. Including, but not limited to:
- Obesity, pregnancy, underlying lung disease (e.g. asthma, pulmonary fibrosis, emphysema), severe injury- hypovolaemia/haemorrhage.
- or any other patient that the treating clinician has a high concern for hypoxemia during RSI.
Exclusion
- Patient is known to be less than 18 years old.
- The patient has a supraglottic device in-situ e.g iGel or LMA.
- The patient is known to be pregnant.
- The patient is known to be a prisoner.
- The patient was intubated in the prehospital environment.
- Immediate need for tracheal intubation precludes preoxygenation i.e. the patient is in cardiac arrest.
Key Trial Info
Start Date :
August 5 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
1400 Patients enrolled
Trial Details
Trial ID
NCT06578468
Start Date
August 5 2024
End Date
December 31 2025
Last Update
September 19 2024
Active Locations (9)
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1
Hennepin Medical Center
Minneapolis, Minnesota, United States, 55451
2
University of New Mexico Medical Center
Albuquerque, New Mexico, United States, 87106
3
Lincoln Medical Center
The Bronx, New York, United States, 10451
4
Westmead Hospital
Sydney, New South Wales, Australia, 2000