Status:
RECRUITING
Cardiac Rehabilitation and Coronary Artery Disease
Lead Sponsor:
Instituto Nacional de Cardiologia de Laranjeiras
Collaborating Sponsors:
Rio de Janeiro State University
Conditions:
Coronary Artery Disease
Atherosclerosis
Eligibility:
All Genders
40-70 years
Phase:
NA
Brief Summary
Patients with coronary artery disease (CAD) aged 40-70 years will undergo exercise training (thrice weekly for 12 weeks). A reference group composed of healthy individuals will be included. Evaluation...
Detailed Description
Participants and recruitment: In this clinical trial, 28 patients with CAD will be enrolled from the Pedro Ernesto University Hospital (HUPE) and 22 control volunteers without evidence of CAD (CTL) wi...
Eligibility Criteria
Inclusion
- Eligible CAD patients will be those aged 40 to 70 years, of both sexes, entering the cardiac rehabilitation program at HUPE. CAD will be defined as any acute coronary syndrome, including myocardial infarction with and without ST-segment elevation, and unstable angina (all defined by characteristic histories, electrocardiographic abnormalities, and cardiac enzyme abnormalities), or obstructive CAD diagnosed via coronary angiography (defined as ≥ 50% stenosis of any epicardial coronary artery) in patients with stable angina.
- Healthy controls: adults aged 40 to 70 years, of both sexes, without CAD evidence.
Exclusion
- diagnosis of heart failure, pulmonary disease, Chagas disease, or tuberculosis
- regular physical exercise practice (≥ 3 days/week for 30 min) over the past 6 months
- malnutrition (body mass index \[BMI\] \< 18.5 kg/m²)
- smoking
- obesity (BMI ≥ 30 kg/m²)
Key Trial Info
Start Date :
October 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06579807
Start Date
October 1 2024
End Date
December 31 2026
Last Update
April 30 2025
Active Locations (1)
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1
Rio de Janeiro State University
Rio de Janeiro, Rio de Janeiro, Brazil, 20550-900