Status:
ENROLLING_BY_INVITATION
Precision Care for Major Depressive Disorder
Lead Sponsor:
University of California, San Francisco
Conditions:
Major Depressive Disorder
Depression
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This study aims to assess whether phenotyping-guided intervention selection is superior to intervention selection without phenotyping guidance (i.e., routine clinician and patient judgment regarding t...
Detailed Description
This study will classify patients seen in the Depression Clinic of the UCSF Department of Psychiatry and Behavioral Sciences into one of five phenotypes (subtypes), including: 1) Anhedonia, 2) Cogniti...
Eligibility Criteria
Inclusion
- Participant is able to provide informed consent
- English speaker
- 18 years of age or older at time of consent
- Meets DSM-5 criteria for Major Depressive Disorder
- The subject meets eligibility criteria for at least one study phenotype as determined by assessments, imaging and/or clinical judgment.
- PHQ-8 score at baseline of \>= 10
- Scheduled for or completed intake in UCSF outpatient psychiatry
Exclusion
- Unstable or untreated medical or psychiatric condition based on clinical assessment by investigator(s)
- Significant risk of suicidal or violent behavior as determined by clinical judgement
- In the Investigators' opinion, the subject is not capable of adhering to the protocol requirements, or the subject has a history of poor or suspected poor compliance in clinical research studies, or the subject has a history of poor or suspected poor compliance to antidepressant medication or that study participation is not in their best interest (e.g., different treatment is indicated given their clinical presentation)
- Pregnant or breastfeeding or planning to become pregnant during the study
Key Trial Info
Start Date :
November 12 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2029
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06580041
Start Date
November 12 2024
End Date
September 1 2029
Last Update
September 5 2025
Active Locations (1)
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1
Nancy Friend Pritzker Psychiatry Building, University of California, San Francisco
San Francisco, California, United States, 94107