Status:
COMPLETED
Krill Oil for Pain in Elders
Lead Sponsor:
University of Florida
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Chronic Musculoskeletal Pain
Eligibility:
All Genders
60+ years
Phase:
PHASE2
Brief Summary
Chronic musculoskeletal pain contributes to mobility disability among older adults. Nutritional interventions, like omega-3 fatty acids, may help manage pain and improve physical function. Supplementa...
Detailed Description
Mobility is a critical factor in the maintenance of independence and quality of life of older adults. Chronic musculoskeletal pain contributes to mobility disability disproportionately among older adu...
Eligibility Criteria
Inclusion
- Able to provide informed consent
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Male or female, aged ≥60 years
- Exhibiting chronic musculoskeletal pain of the hip, knees, or lower back (\>3 months)
- Average pain ≥4 on a 0-10 numeric rating scale
- Exhibiting moderate mobility limitations (Short Physical Performance Battery score 4-10)
- Ability to take oral supplements and be willing to adhere to the supplementation regimen
- Agreement to adhere to Lifestyle Considerations throughout study duration
Exclusion
- Any known coagulation or bleeding disorders
- Standing regimen of anticoagulants or full-dose aspirin
- Regular use of opioids or high-dose NSAIDs
- Taking medication known to affect muscle (e.g. steroids)
- Taking selective serotonin reuptake inhibitors (SSRIs)
- Omega-3 supplementation within the past 3 months
- High consumption of fatty fish (\>2 servings/week)
- Habitual supplementation with other complementary medicines/supplements that may affect the study results, including St. John's Wort
- Known allergy to seafood
- Clinically significant conditions: diabetes, severe cardiovascular disease, seizure disorders, uncontrolled hypertension (\>150/90mmhg at baseline), cancer or cancer that has been in remission \>5 years
- History of atrial fibrillation or atrial flutter
- Dementia
- History of smoking, alcohol abuse, or illicit drug use
- Ambulatory impairments which would limit the ability to perform physical function tests
- Treatment with another investigational drug or other intervention within 3 months
- Planning a surgical procedure during the study period
- Planning to permanently leave the area during the study period
Key Trial Info
Start Date :
January 17 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 17 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06580912
Start Date
January 17 2025
End Date
December 17 2025
Last Update
January 7 2026
Active Locations (1)
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1
UF Claude D. Pepper Older Americans Independence Center
Gainesville, Florida, United States, 32610