Status:
ACTIVE_NOT_RECRUITING
Efficacy and Safety of High-Flow Nasal Cannula Versus Noninvasive Ventilation for Pulmonary Arterial Hypertension-Associated Acute Respiratory Failure
Lead Sponsor:
The First People's Hospital of Neijiang
Conditions:
Pulmonary Arterial Hypertension
Acute Respiratory Failure
Eligibility:
All Genders
18-90 years
Brief Summary
This is a single center, retrospective, propensity score matching cohort study that explores the efficacy and safety of high flow nasal cannula and non-invasive ventilation in the treatment of acute r...
Detailed Description
Study Title: Efficiency and Safety of High Flow Nassal Cannula Versus Noninvasive Ventilation for Pulsary Arterial Hypertension Associated Acute Respiratory Failure: A Retrospective Cohort Study Strat...
Eligibility Criteria
Inclusion
- Inclusion criteria are patients aged ≥ 18 years old；
- Patients diagnosed with PH based on right ventricular systolic pressure (RVSP)\>50 mmHg on echocardiography or right heart catheterization (resting mean pulmonary artery pressure ≥ 25 mmHg)；
- And patients who require HFNC or NIV respiratory support after ACRF (defined as acute deterioration of respiratory function in patients with chronic respiratory diseases, resulting in PaO2\<60 mmHg, PaO2/FiO2 ratio\<300 mmHg, or respiratory rate\>30 breaths per minute in indoor air).
Exclusion
- The exclusion criteria were patients with acute coronary syndrome, acute myocardial infarction, severe arrhythmias, severe cerebrovascular or neurological diseases, and severe hepatic or renal dysfunction;
- those who were receiving endotracheal intubation or NIV within 24 h of admission;
- patients who were not intubated;
- those who were receiving palliative care;
- immunocompromised patients;
- patients with incomplete data or who were lost to follow-up.
Key Trial Info
Start Date :
January 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2025
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06582459
Start Date
January 1 2023
End Date
January 1 2025
Last Update
September 3 2024
Active Locations (1)
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1
The First People's Hospital of Neijiang City
Neijiang, Sichuan, China, 641000