Status:
RECRUITING
Aging, Beta Blockers, and Thermoregulatory Responses
Lead Sponsor:
University of Texas Southwestern Medical Center
Conditions:
Heat Stress
Aging
Eligibility:
All Genders
65+ years
Phase:
PHASE4
Brief Summary
This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.
Detailed Description
Older individuals are more likely to die or become ill during heat waves. During the 1995 Chicago heat wave, there was 35% increase in hospital admissions for individuals older than 65 years of age. M...
Eligibility Criteria
Inclusion
- Healthy and free of any significant medical problems
- Normal resting electrocardiogram
- 65+ years of age
- Controlled cholesterol of less than 200 mg/dl
- Controlled blood pressure of less than 140/90 mmHg
Exclusion
- Known diseases or other chronic conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia
- Serious abnormalities detected on routine screening
- Taking prescribed medications or over-the-counter medications that have known influences on either cardiac function or sweating
- Current smokers, as well as individuals who regularly smoked within the past 3 years
- body mass index ≥31 kg/m2
Key Trial Info
Start Date :
October 4 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2026
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT06582680
Start Date
October 4 2024
End Date
September 30 2026
Last Update
October 23 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
IEEM Texas Health Presbyterian Hospital Dallas
Dallas, Texas, United States, 75231