Status:
RECRUITING
Lynch Syndrome Integrative Epidemiology and Genetics
Lead Sponsor:
University of Colorado, Denver
Collaborating Sponsors:
University of Chicago
University of Kansas
Conditions:
Lynch Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
The vision of the "Lynch syndrome INtegrative Epidemiology And GEnetics" (LINEAGE) Consortium is to collaboratively improve the lives and longevity of individuals and families with Lynch syndrome. Th...
Detailed Description
The main objective of this consortium is to build a shared resource to drive research in critical areas necessary to understand LS-related neoplasia risk and improve early detection and prevention of ...
Eligibility Criteria
Inclusion
- • Adults age over 18 years
- Eligible patients must have at least one variant of uncertain significance (VUS), pathogenic or likely pathogenic variant (PV/LPV) in MLH1, MSH2, MSH6, PMS2, or EPCAM, which will be confirmed by genetic testing results (obtained as part of routine care) and a review of the variant in ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/).
- Individuals who are an obligate carrier of a LS PV/LPV that is confirmed in the family.
Exclusion
- Age under 18
Key Trial Info
Start Date :
October 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2054
Estimated Enrollment :
5000 Patients enrolled
Trial Details
Trial ID
NCT06582914
Start Date
October 1 2024
End Date
December 31 2054
Last Update
January 15 2025
Active Locations (2)
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1
University of Colorado
Aurora, Colorado, United States, 80045
2
University of Chicago
Chicago, Illinois, United States, 60637