Status:
RECRUITING
A Multicenter Study Based on Multi-omics Analysis to Predict the Early Prognosis and Recurrence Risk of Acute Ischemic Stroke
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Conditions:
Ischemic Stroke, Acute
Eligibility:
All Genders
18-75 years
Brief Summary
Through a multicenter prospective AIS cohort study, we analyze the potential association of human proteome, microbiome and metabolome alterations with AIS prognosis, searching for key proteins, differ...
Detailed Description
Currently, the burden of brain vascular disease in China is the highest in the world, and among them, the incidence rate of acute ischemic stroke (AIS) is high, the recurrence rate is high, the disabi...
Eligibility Criteria
Inclusion
- Meet the diagnostic criteria of AIS according to the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018
- Aged 18 to 75 years old
- Stroke within 7 days of onset
- Sign informed consent, provide relevant medical history information and provide biological specimens
Exclusion
- Severe impairment of consciousness (awareness score of NIHSS\>1)
- History of stroke within 12 months
- Severe systemic disease including malignancy
- ALT or AST\> 2 times the upper limit of normal or severe liver disease
- creatinine \> 1.5 times the upper limit of normal or severe kidney disease
- History of long-term drinking, drug use, and chemical poisoning (e.g., pesticide poisoning); Note: Long-term alcohol consumption, usually more than 5 years, over 40 g/day of alcohol for men and 20 g/day for women, or a history of heavy alcohol consumption within 2 weeks, over 80 g/day of alcohol
- History of intestinal tumors, irritable bowel syndrome or inflammatory bowel disease or confirmed in the hospital
- Unable to collect a stool specimen within 4 days of admission
- Assessed to be unsuitable for participation in this study by the investigator
Key Trial Info
Start Date :
January 30 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2028
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT06584565
Start Date
January 30 2024
End Date
December 31 2028
Last Update
September 5 2024
Active Locations (1)
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1
Nanfang Hospital,Southern Medical University
Guangzhou, Guangdong, China, 510515