Status:
COMPLETED
Understanding Cerebral Blood Flow Dynamics for Alzheimer's Disease Prevention Through Exercise
Lead Sponsor:
Universidad de Granada
Collaborating Sponsors:
University Hospital Virgen de las Nieves
Instituto Mixto Universitario Deporte y Salud (iMUDS)
Conditions:
Healthy Aging
Cognitive Function 1, Social
Eligibility:
All Genders
68-83 years
Phase:
NA
Brief Summary
Dementia is one of the leading causes of disability worldwide. Underlying biological mechanisms are crucial in preclinical stages of Alzheimer's disease (AD). Alterations in cerebral blood flow (CBF) ...
Detailed Description
The aging population is at an increasing risk of developing Alzheimer's Disease (AD), which is characterized by cognitive decline and memory loss. Current pharmacological treatments have targeted amyl...
Eligibility Criteria
Inclusion
- Older adults
- Aged 68-83 years
- Non-pathological cerebral beta-amyloid status (based on Centiloid cut-point \<12 measured by PET-CT)
- APOEe4 negative status
- Willingness to participate in exercise interventions
Exclusion
- Pathological diagnosis related to physical or mental condition
- No living in community settings during the study
- MRI incompatibility
- Ambulatory with pain or regular use of an assisted walking device
- Severe cardiovascular or respiratory conditions
- Participation in another clinical trial within the last 30 days
Key Trial Info
Start Date :
September 25 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 2 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06584656
Start Date
September 25 2024
End Date
January 2 2025
Last Update
March 25 2025
Active Locations (2)
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1
University of Granada
Granada, Andalusia, Spain, 18016
2
Mind, Brain, and Behaviour Research Centre (CIMCYC, Centro de Investigación Mente, Cerebro y Comportamiento)
Granada, Spain, 18011