Status:

RECRUITING

DoseTB-individualised Dosing by Model-informed Precision Dosing for Pulmonary Tuberculosis

Lead Sponsor:

Karolinska Institutet

Collaborating Sponsors:

Karolinska University Hospital

Region Östergötland

Conditions:

Tuberculosis, Pulmonary

Eligibility:

All Genders

18+ years

Brief Summary

The goal of this observational study is to investigate whether model-informed precision dosing (MIPD), as a clinical support for early individualised dosing in addition to the national TB care program...

Detailed Description

Background: Individualised treatment for tuberculosis (TB) to improve treatment outcome has still some substantial obstacles to pass before becoming a reality in clinical practice. Previous studies, ...

Eligibility Criteria

Inclusion

  • Inclusion criteria
  • Adult persons ≥18 years with confirmed pulmonary TB (established through Mtb cultures or PCR for Mtb by clinical routine)
  • Ongoing or planned treatment of TB that includes rifampin
  • Written informed consent
  • Exclusion criteria
  • TB treatment with rifampin for longer than 8 weeks prior to inclusion
  • TB treatment with intravenous rifampin (including patients treated at an intensive care unit (ICU) or patients with cerebral TB)
  • TDM of rifampin has already been performed (\>24 h before inclusion) by clinical routine
  • Study participants with extrapulmonary TB without pulmonary TB.

Exclusion

    Key Trial Info

    Start Date :

    November 1 2025

    Trial Type :

    OBSERVATIONAL

    Allocation :

    ESTIMATED

    End Date :

    December 1 2027

    Estimated Enrollment :

    30 Patients enrolled

    Trial Details

    Trial ID

    NCT06585358

    Start Date

    November 1 2025

    End Date

    December 1 2027

    Last Update

    November 21 2025

    Active Locations (2)

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    Page 1 of 1 (2 locations)

    1

    Linköping University Hospital

    Linköping, Sweden

    2

    Karolinska University Hospital

    Stockholm, Sweden, 17177

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