Status:
COMPLETED
Establishment of Multimodal-multiparametric Progressive Prediction Models for Thyroid Associated Ophthalmopathy
Lead Sponsor:
Shanghai Changzheng Hospital
Conditions:
Thyroid-Associated Ophthalmopathy
Eligibility:
All Genders
18-80 years
Brief Summary
Thyroid-associated ophthalmopathy (TAO) is an organ-specific autoimmune disease closely related to thyroid disease, which leads the incidence of orbital disease in adults and is the most common cause ...
Eligibility Criteria
Inclusion
- According to the Bartley criteria，diagnosed TAO from 2017/1/1 to 2024/3/31
- Moderate to severe patients defined by EUGOGO
- CAS ≥4 (on the 7-item scale) for the study eye
- Completed orbital MRI at our hospital
- Received complete medical treatment and completed assessment at our hospital
Exclusion
- Anticipated need for intervention due to sight-threatening complications or other significant and acute deterioration in vision
- History of systemic (eg, oral or IV) steroid use with a cumulative dose equivalent to \< 1 g of methylprednisolone for the treatment of TAO.
- Any major illness/condition or evidence of an unstable clinical condition that, in the investigators judgment, will substantially increase the risk to the participant, or confound the interpretation of safety assessments, if they were to participate in the study
- Any other condition that, in the opinion of the investigator, would impair the ability of the participant to comply with the study procedures or impair the ability to interpret data from the participants participation in the study
- Pregnant or lactating
- Any other condition that,would impair the ability of the participant to undergo orbital MRI
Key Trial Info
Start Date :
January 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 31 2024
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT06585592
Start Date
January 1 2017
End Date
March 31 2024
Last Update
July 1 2025
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